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By the time you finish this article you should have all the insight you need to score big fantasy points this weekend. England are out of sorts, on a two match losing streak, shorn of some of their top talent and facing unquestionably the form team of the tournament.
So what could possibly go wrong for Ireland? The bookies agree, unable to separate the two teams, with no handicap advantage to either side.
Too close to call. Italy have found things particularly hard going this year, whilst Scotland, despite a major blip in Cardiff, have impressed. A seemingly obvious point, but in a short tournament, every point is precious. You do not want to be cursing yourself afterwards because you forgot to check that the Italian prop you had in week one has been benched.
Teams generally make only a few changes, Declan Kidney rarely makes more than a couple of alterations unless they are enforced, though the Italians, on the other hand, can make wholesale changes that you may not notice unless you're clued in. Team announcenments are always a few days in advance of the games so you have no excuses. While in theory it would be nice to go for three in the front-row, two locks and three in the back row, this is about winning.
Back rowers can be real points earners, as they are try scorers and often man-of-the-match contenders. Considering you lose a point if your player is subbed off, they can be high risk. Coupled with the fact that props are more than prone to ten minutes on the sideline, they may not be worth putting in the side.
While it is just five weekends of rugby, you must keep in mind the final week. It is all well and fine being in contention only to realise that on the final weekend you have seven players not starting but only five changes you can make. Injuries, form and suspensions can have a major impact on your selections, as many changes will be forced. GMT -- France vs. GMT -- Italy vs. All roads point to a big England win over Italy in Rome so you want to make sure your team is stacked with a full compliment -- four players -- of Eddie Jones' starting side.
It would be wise to select at least two of your England players in the outside backs for the best chance of picking up points for tries scored. Jonny May has the ability to run rings around the Italian defence from the wing while some extra space for Anthony Watson at fullback could see him flourish. Sam Simmonds could thrive off the back of an England scrum too.
The worst thing that can happen to your Fantasy team is keeping a player in your squad who isn't even going to feature on the pitch. Rhys Webb was an early candidate to be one of the top scrum-half picks in the competition, but a knee injury will prevent him from playing any part in the Six Nations this term.
His half-back partner Dan Biggar is set to miss Wales' first three matches with a shoulder problem. If you were taking a punt on Zach Mercer starting in the back row for England, it's worth your while changing your mind with the uncapped No.
Who should I bring in? Moriarty has been picked to start at No. Maro Itoje is worth your selection after overcoming a hip injury in time for England's Six Nations opener against Italy while Ulster's Jacob Stockdale has returned to full fitness in time to take a place on the wing for Ireland against France in Paris.